2jsd | pdb_00002jsd
Solution structure of MMP20 complexed with NNGH
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Overview
The solution structure of the catalytic domain of MMP-20, a member of the, matrix metalloproteinases family not yet structurally characterized, complexed with N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic, acid (NNGH), is here reported and compared with other MMPs-NNGH adducts., The backbone dynamic has been characterized as well. We have found that, despite the same fold and very high overall similarity, the present, structure experiences specific structural and dynamical similarities with, some MMPs and differences with others, around the catalytic cavity. The, present solution structure, not only contributes to fill the gap of, structural knowledge on human MMPs, but also provides further information, to design more selective and efficient inhibitors for a specific member of, this class of proteins.
About this Structure
2JSD is a Single protein structure of sequence from Homo sapiens with CA, ZN and NGH as ligands. Full crystallographic information is available from OCA.
Reference
Catalytic domain of MMP20 (Enamelysin) - the NMR structure of a new matrix metalloproteinase., Arendt Y, Banci L, Bertini I, Cantini F, Cozzi R, Del Conte R, Gonnelli L, FEBS Lett. 2007 Oct 2;581(24):4723-6. Epub 2007 Sep 6. PMID:17869250
Page seeded by OCA on Wed Jan 23 12:08:28 2008
