1xkk | pdb_00001xkk
From Proteopedia
EGFR kinase domain complexed with a quinazoline inhibitor- GW572016
About this Structure
1xkk is a 1 chain structure of Epidermal Growth Factor Receptor with sequence from Homo sapiens. The June 2010 RCSB PDB Molecule of the Month feature on Epidermal Growth Factor Receptor by David Goodsell is 10.2210/rcsb_pdb/mom_2010_6. Full crystallographic information is available from OCA.
See Also
Reference
- Wood ER, Truesdale AT, McDonald OB, Yuan D, Hassell A, Dickerson SH, Ellis B, Pennisi C, Horne E, Lackey K, Alligood KJ, Rusnak DW, Gilmer TM, Shewchuk L. A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res. 2004 Sep 15;64(18):6652-9. PMID:15374980 doi:10.1158/0008-5472.CAN-04-1168
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Epidermal Growth Factor Receptor
- Homo sapiens
- RCSB PDB Molecule of the Month
- Transferase
- Alligood, K J.
- Dickerson, S H.
- Ellis, B.
- Gilmer, T M.
- Hassell, A.
- Horne, E.
- Lackey, K.
- McDonald, O B.
- Pennisi, C.
- Rusnak, D W.
- Shewchuk, L M.
- Truesdale, A T.
- Wood, E R.
- Yuan, D.
- Egfr
- Epidermal growth factor receptor
- Kinase
