3ghv | pdb_00003ghv

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File:3ghv.png

Template:STRUCTURE 3ghv

Human dihydrofolate reductase Q35K/N64F double mutant inhibitor complex

Template:ABSTRACT PUBMED 19719239

About this Structure

3ghv is a 1 chain structure of Dihydrofolate reductase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Gangjee A, Li W, Kisliuk RL, Cody V, Pace J, Piraino J, Makin J. Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. J Med Chem. 2009 Aug 13;52(15):4892-902. PMID:19719239 doi:10.1021/jm900490a

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OCA

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