1gj5 | pdb_00001gj5
From Proteopedia
SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN
About this Structure
1gj5 is a 3 chain structure of Hirudin with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Katz BA, Sprengeler PA, Luong C, Verner E, Elrod K, Kirtley M, Janc J, Spencer JR, Breitenbucher JG, Hui H, McGee D, Allen D, Martelli A, Mackman RL. Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets. Chem Biol. 2001 Nov;8(11):1107-21. PMID:11731301
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Thrombin
- Allen, D.
- Breitenbucher, J G.
- Hui, H.
- Katz, B A.
- Luong, C.
- Mackman, R L.
- Martelli, A.
- McGee, D.
- Spencer, J R.
- Sprengeler, P A.
- Verner, E.
- Blood clotting
- Hydrolase
- Oxyanion hole water
- Shift of pka of his57
- Specificity
- Structure-based drug design
- Three-centered
- Trypsin
- Urokinase
- Very short hydrogen bond
- Zn+2-mediated inhibition
