Sandbox Reserved 347

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.

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Introduction

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='2iko' size='350' frame='false' scene=
2iko, resolution 1.90Å (default scene)
Ligands:	7IG
Gene:	REN (Homo sapiens)
Activity:	Renin, with EC number 3.4.23.15
Structural annotation: Resources: InterPro : Ipr009007, Ipr001461, Ipr012848, Ipr001969 Pfam : PF00026 UniProt : P00797
Functional annotation: Cellular component: extracellular space membrane Biological process: regulation of MAPKKK cascade regulation of blood pressure proteolysis angiotensin maturation Molecular function: hydrolase activity peptidase activity pepsin A activity renin activity receptor binding aspartic-type endopeptidase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Renin (pronounced /ˈriːnɨn/ REE-nin), also known as angiotensinogenase is an enzyme that participates in the body's renin-angiotensin system (RAS) that mediates extracellular volume (i.e., that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction.

Thus, it regulates the body's mean arterial blood pressure.

Biochemistry

Renin is an aspartyl protease.

Function

Renin plays a key role in the Renin-Angiotension sysmtem (RAS). This system is responsible for the control of blood pressure and salt balances in mammals.