2dz7 | pdb_00002dz7
DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)
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Overview
The crystal structure of the tetragonal form of d(gcGAAAgc) has been, revised and reasonably refined including the disordered residues. The two, DNA strands form a base-intercalated duplex, and the four duplexes are, assembled according to the crystallographic 222 symmetry to form an, octaplex. In the central region, the eight strands are associated by, I-motif of double A-quartets. Furthermore, eight hydrated-magnesium, cations link the four duplexes to support the octaplex formation. Based on, these structural features, a proposal that folding of d(GAAA)n, found in, the non-coding region of genomes, into an octaplex can induce slippage, during replication to facilitate length polymorphism is presented.
About this Structure
2DZ7 is a Protein complex structure of sequences from [1] with MG as ligand. Full crystallographic information is available from OCA.
Reference
DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC)., Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A, J Biochem (Tokyo). 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:17062599
Page seeded by OCA on Wed Jan 23 14:09:35 2008
