Sandbox 80
Template:Tims Sandbox Reservation
This is an antiviral drug used to treat HIV by inhibiting proteases in the virus. This inhibition causes the spread of the virus to decrease significantly. The protease is an enzyme that the virus uses to produce the proteins necessary to assemble more viruses. The common name for saqinavir is fortovase. It functions as peptide-like analogue that binds to active site 1 of the protein and causes inhibition by preventing the protease from cleaving polyproteins which in turn causes the virus to create non-infectious virus particles.
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| 3oxc, resolution 1.16Å (default scene) | |||||||||||||
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| Ligands: | FMT, ROC, SO4 | ||||||||||||
| Gene: | pol (Human immunodeficiency virus 1) | ||||||||||||
| Activity: | HIV-1 retropepsin, with EC number 3.4.23.16 | ||||||||||||
| Related: | 2ien, 3mws, 3nu3, 3cyx, 3d1x, 3d1y, 2nmy, 2nmz, 2nnk, 2nnp | ||||||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Structure
The chemical formula of Saquinavir is (C39)(H54)(N6)(O8)S and the molecular weight is 766.94 g/mol.
Protein and Drug interations
intermolecular forces attraction
References
https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000973 https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60934&loc=ec_rcs#pharmaction
