Simvastatin Synthase

Simvastatin Synthase

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='3hle' size='350' frame='false' scene=
3hle, resolution 2.06Å (default scene)
Ligands:	DTT, MJA
Related:	1hld
Structural annotation: Resources: InterPro : Ipr012338, Ipr001466 Pfam : PF00144
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Simvastatin Synthase, LovD, is an acyltransferase that converts the inactive monacolin J acid (MJA) into the cholesterol-lowering lovastatin. LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst.

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Eric Ginter, Michal Harel, Alexander Berchansky, David Canner