Simvastatin Synthase
From Proteopedia
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| 3hle, resolution 2.06Å (default scene) | |||||||||||||
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| Ligands: | DTT, MJA | ||||||||||||
| Related: | 1hld | ||||||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Introduction
Simvastation synthase (LovD) is an enzyme isolatied from the natural product biosynthetic pathways ofAspergillus terreus. Simvastatin Synthase is an acyltransferase that converts the inactive monacolin J acid (MJA) into the cholesterol-lowering lovastatin.File:LovD copy.jpg
LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst.
Proteopedia Page Contributors and Editors (what is this?)
Eric Ginter, Michal Harel, Alexander Berchansky, David Canner
