2oc8 | pdb_00002oc8

Structure of Hepatitis C Viral NS3 protease domain complexed with NS4A peptide and ketoamide SCH503034

File:2oc8.jpg

spinqualitylabelsall models 2oc8, resolution 2.66Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

Overview

An estimated 1% of the global human population is infected by hepatitis C, viruses (HCVs), and there are no broadly effective treatments for the, debilitating progression of chronic hepatitis C. A serine protease located, within the HCV NS3 protein processes the viral polyprotein at four, specific sites and is considered essential for replication. Thus, it, emerges as an attractive target for drug design. We report here the 2.5, angstrom resolution X-ray crystal structure of the NS3 protease domain, complexed with a synthetic NS4A activator peptide. The protease has a, chymotrypsin-like fold and features a tetrahedrally coordinated metal ion, distal to the active site. The NS4A peptide intercalates within a beta, sheet of the enzyme core.

About this Structure

2OC8 is a Protein complex structure of sequences from Hepatitis c virus with ZN, BME and HU5 as ligands. Full crystallographic information is available from OCA.

Reference

Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide., Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA, Cell. 1996 Oct 18;87(2):343-55. PMID:8861917

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