1ql9 | pdb_00001ql9

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File:1ql9.png

Template:STRUCTURE 1ql9

FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH RAT TRYPSIN MUTANT X99RT

Template:ABSTRACT PUBMED 12527302

About this Structure

1ql9 is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  1. Reyda S, Sohn C, Klebe G, Rall K, Ullmann D, Jakubke HD, Stubbs MT. Reconstructing the binding site of factor Xa in trypsin reveals ligand-induced structural plasticity. J Mol Biol. 2003 Jan 31;325(5):963-77. PMID:12527302
  2. Renatus M, Bode W, Huber R, Sturzebecher J, Stubbs MT. Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase. J Med Chem. 1998 Dec 31;41(27):5445-56. PMID:9876114 doi:10.1021/jm981068g
  3. Stubbs MT, Huber R, Bode W. Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin. FEBS Lett. 1995 Nov 13;375(1-2):103-7. PMID:7498454

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