3ndm | pdb_00003ndm
From Proteopedia
Crystal structure of Rho-Associated Protein Kinase (ROCK1) with a potent isoquinolone derivative
About this Structure
3ndm is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Bosanac T, Hickey ER, Ginn J, Kashem M, Kerr S, Kugler S, Li X, Olague A, Schlyer S, Young ER. Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3746-9. Epub 2010 Apr 21. PMID:20471253 doi:10.1016/j.bmcl.2010.04.069
- Ginn JD, Bosanac T, Chen R, Cywin C, Hickey E, Kashem M, Kerr S, Kugler S, Li X, Prokopowicz A 3rd, Schlyer S, Smith JD, Turner MR, Wu F, Young ER. Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 2, optimization for blood pressure reduction in spontaneously hypertensive rats. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5153-6. Epub 2010 Aug 1. PMID:20678931 doi:10.1016/j.bmcl.2010.07.014
