2vuk | pdb_00002vuk
From Proteopedia
STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO THE STABILIZING SMALL-MOLECULE DRUG PHIKAN083
About this Structure
2vuk is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Boeckler FM, Joerger AC, Jaggi G, Rutherford TJ, Veprintsev DB, Fersht AR. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5. Epub 2008 Jul 23. PMID:18650397
- Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Boeckler, F M.
- Fersht, A R.
- Joerger, A C.
- Acetylation
- Activator
- Alternative splicing
- Anti-oncogene
- Apoptosis
- Cancer
- Cell cycle
- Covalent protein-rna linkage
- Cytoplasm
- Disease mutation
- Dna binding
- Dna-binding
- Dna-binding protein
- Endoplasmic reticulum
- Glycoprotein
- Host-virus interaction
- Li-fraumeni syndrome
- Metal binding
- Metal-binding
- Methylation
- Nuclear protein
- Nucleus
- P53 dna- binding domain
- Phosphoprotein
- Polymorphism
- Protein stabilization
- Second-site suppressor mutation
- Small-molecule drug
- Superstable mutant
- Surface crevice
- Transcription
- Transcription regulation
- Tumor suppressor
- Ubl conjugation
- Virtual screening
- Zinc
