3g1m | pdb_00003g1m

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File:3g1m.png

Template:STRUCTURE 3g1m

EthR from Mycobacterium tuberculosis in complex with compound BDM31381

Template:ABSTRACT PUBMED 19412174

About this Structure

3g1m is a 1 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

  1. Willand N, Dirie B, Carette X, Bifani P, Singhal A, Desroses M, Leroux F, Willery E, Mathys V, Deprez-Poulain R, Delcroix G, Frenois F, Aumercier M, Locht C, Villeret V, Deprez B, Baulard AR. Synthetic EthR inhibitors boost antituberculous activity of ethionamide. Nat Med. 2009 May;15(5):537-44. Epub 2009 May 3. PMID:19412174 doi:10.1038/nm.1950
  2. Frenois F, Baulard AR, Villeret V. Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis. Tuberculosis (Edinb). 2006 Mar;86(2):110-4. Epub 2005 Oct 21. PMID:16243584 doi:10.1016/j.tube.2005.07.005
  3. Frenois F, Engohang-Ndong J, Locht C, Baulard AR, Villeret V. Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosis. Mol Cell. 2004 Oct 22;16(2):301-7. PMID:15494316 doi:10.1016/j.molcel.2004.09.020
  4. Engohang-Ndong J, Baillat D, Aumercier M, Bellefontaine F, Besra GS, Locht C, Baulard AR. EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator. Mol Microbiol. 2004 Jan;51(1):175-88. PMID:14651620

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