2dqu | pdb_00002dqu

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Template:STRUCTURE 2dqu

File:2dqu.png

Crystal form II: high resolution crystal structure of the complex of the hydrolytic antibody Fab 6D9 and a transition-state analog

Template:ABSTRACT PUBMED 17428500

About this Structure

2dqu is a 2 chain structure with sequence from Mus musculus. This structure supersedes the now removed PDB entry 1hyy. Full crystallographic information is available from OCA.

Reference

  1. Oda M, Ito N, Tsumuraya T, Suzuki K, Sakakura M, Fujii I. Thermodynamic and structural basis for transition-state stabilization in antibody-catalyzed hydrolysis. J Mol Biol. 2007 May 25;369(1):198-209. Epub 2007 Mar 15. PMID:17428500 doi:10.1016/j.jmb.2007.03.023
  2. Miyashita H, Hara T, Tanimura R, Fukuyama S, Cagnon C, Kohara A, Fujii I. Site-directed mutagenesis of active site contact residues in a hydrolytic abzyme: evidence for an essential histidine involved in transition state stabilization. J Mol Biol. 1997 Apr 18;267(5):1247-57. PMID:9150409 doi:10.1006/jmbi.1997.0938
  3. Miyashita H, Hara T, Tamimura R, Tanaka F, Kikuchi M, Fujii I. A common ancestry for multiple catalytic antibodies generated against a single transition-state analog. Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10757. PMID:7938025
  4. Miyashita H, Hara T, Tanimura R, Tanaka F, Kikuchi M, Fujii I. A common ancestry for multiple catalytic antibodies generated against a single transition-state analog. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6045-9. PMID:8016113
  5. Miyashita H, Karaki Y, Kikuchi M, Fujii I. Prodrug activation via catalytic antibodies. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5337-40. PMID:8506382

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