3mdm | pdb_00003mdm
From Proteopedia
Thioperamide complex of Cytochrome P450 46A1
Template:ABSTRACT PUBMED 20667828
About this Structure
3mdm is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Mast N, Charvet C, Pikuleva IA, Stout CD. Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain. J Biol Chem. 2010 Oct 8;285(41):31783-95. Epub 2010 Jul 28. PMID:20667828 doi:10.1074/jbc.M110.143313
- Mast N, White MA, Bjorkhem I, Johnson EF, Stout CD, Pikuleva IA. Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9546-51. Epub 2008 Jul 9. PMID:18621681
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Cholesterol 24-hydroxylase
- Homo sapiens
- Charvet, C.
- Mast, N.
- Pikuleva, I.
- Stout, C D.
- Cholesterol metabolism
- Cyp46a1
- Endoplasmic reticulum
- Heme
- Iron
- Lipid metabolism
- Membrane
- Metabolic enzyme
- Metal-binding
- Microsome
- Monooxygenase
- Nadp
- Oxidoreductase
- P450
- P450 46a1
- Steroid metabolism
- Thioperamide
- Transmembrane
