1w51 | pdb_00001w51
|
BACE (BETA SECRETASE) IN COMPLEX WITH A NANOMOLAR NON-PEPTIDIC INHIBITOR
Overview
Human BACE, also known as beta-secretase, shows promise as a potential, therapeutic target for Alzheimer's disease. We determined the apo, structure of BACE to 1.75 A, and a structure of a hydroxyethylamine, inhibitor complex derived by soaking. These show significant active-site, movements compared to previously described BACE structures. Additionally, the structures reveal two pockets that could be targeted by, structure-based drug design.
About this Structure
1W51 is a [Single protein] structure of sequence from [Homo sapiens] with IOD and L01 as [ligands]. Active as [Memapsin 2], with EC number [3.4.23.46]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Apo and inhibitor complex structures of BACE (beta-secretase)., Patel S, Vuillard L, Cleasby A, Murray CW, Yon J, J Mol Biol. 2004 Oct 15;343(2):407-16. PMID:15451669
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