2xpk | pdb_00002xpk

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Template:STRUCTURE 2xpk

File:2xpk.jpg

CELL-PENETRANT, NANOMOLAR O-GLCNACASE INHIBITORS SELECTIVE AGAINST LYSOSOMAL HEXOSAMINIDASES

Template:ABSTRACT PUBMED 21095575

About this Structure

2xpk is a 2 chain structure with sequence from Clostridium perfringens. Full crystallographic information is available from OCA.

Reference

  1. Dorfmueller HC, Borodkin VS, Schimpl M, Zheng X, Kime R, Read KD, van Aalten DM. Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases. Chem Biol. 2010 Nov 24;17(11):1250-5. PMID:21095575 doi:10.1016/j.chembiol.2010.09.014

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