Reserved Sandbox 329
From Proteopedia
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| 2q0d, resolution 2.00Å (default scene) | |||||||||||||
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| Ligands: | ATP, MG | ||||||||||||
| Gene: | TUT4 (Trypanosoma brucei) | ||||||||||||
| Activity: | RNA uridylyltransferase, with EC number 2.7.7.52 | ||||||||||||
| Related: | 2ikf, 2nom | ||||||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Uridylyl transferases
INTRODUCTION
Terminal uridylyl transferases (TUTases) belong to a superfamily of polymerase ß nucleotidyl transferases.[1] TUTases have been isolated from Trypanosoma brucei and also Leishmania ssp, parasites causing diseases in humans such as African Sleeping Sickness.
The bound ligand is an ATP complex with two Mg2+ ions.
References
1. Stagno J, Aphasizheva I, Aphasizhev R, Luecke H. Dual role of the RNA substrate in selectivity and catalysis by terminal uridylyl transferases. Proc Natl Acad Sci USA. 2007 Sep;107(37):14634–14639. PMID:17785418
