Sandbox Reserved 194

This Sandbox is Reserved from Feb 02, 2011, through Jul 31, 2011 for use by the Biochemistry II class at the Butler University at Indianapolis, IN USA taught by R. Jeremy Johnson. This reservation includes Sandbox Reserved 191 through Sandbox Reserved 200.

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spinqualitylabelsall models Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

File:1RTA zoom.png

Thymidylic acid tetramer complexed with ribonuclease A

To determine the structural characteristics of RNA substrate binding to RNase A, X-ray crystallography was used to image inhibitory DNA tetramers bound to the enzyme. DNA lacks the 2′OH essential to RNA cleavage, making the complex more conducive to crystallography. In previous studies, the RNase A - thymidylic acid tetramer (d(pT)4) complex has provided information into the specificity of the binding pocket subunits, B0, B1, B2 and B3.

File:1RCN zoom.png

ApTpApApG complexed with ribonuclease A