1h0b | pdb_00001h0b
ENDOGLUCANASE CEL12A FROM RHODOTHERMUS MARINUS
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Overview
Cellulose is one of the most abundant polysaccharides in nature and, microorganisms have developed a comprehensive system for enzymatic, breakdown of this ubiquitous carbon source, a subject of much interest in, the biotechnology industry. Rhodothermus marinus produces a, hyperthermostable cellulase, with a temperature optimum of more than 90, degrees C, the structure of which is presented here to 1.8 A resolution., The enzyme has been classified into glycoside hydrolase family 12; this is, the first structure of a thermophilic member of this family to have been, solved. The beta-jelly roll fold observed has identical topology to those, of the two mesophilic members of the family whose structures have been, elucidated previously. A Hepes buffer molecule bound in the active site, may have ... [(full description)]
About this Structure
1H0B is a [Single protein] structure of sequence from [Rhodothermus marinus] with EPE as [ligand]. Active as [Cellulase], with EC number [3.2.1.4]. Structure known Active Site: HE1. Full crystallographic information is available from [OCA].
Reference
The structure of Rhodothermus marinus Cel12A, a highly thermostable family 12 endoglucanase, at 1.8 A resolution., Crennell SJ, Hreggvidsson GO, Nordberg Karlsson E, J Mol Biol. 2002 Jul 19;320(4):883-97. PMID:12095262
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