200d | pdb_0000200d
STABLE LOOP IN THE CRYSTAL STRUCTURE OF THE INTERCALATED FOUR-STRANDED CYTOSINE-RICH METAZOAN TELOMERE
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Overview
In most metazoans, the telomeric cytosine-rich strand repeating sequence, is d(TAACCC). The crystal structure of this sequence was solved to 1.9-A, resolution. Four strands associate via the cytosine-containing parts to, form a four-stranded intercalated structure held together by C.C+ hydrogen, bonds. The base-paired strands are parallel to each other, and the two, duplexes are intercalated into each other in opposite orientations. One, TAA end forms a highly stabilized loop with the 5' thymine, Hoogsteen-base-paired to the third adenine. The 5' end of this loop is in, close proximity to the 3' end of one of the other intercalated cytosine, strands. Instead of being entirely in a DNA duplex, this structure, suggests the possibility of an alternative conformation for the, cytosine-rich telomere strands.
About this Structure
200D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Stable loop in the crystal structure of the intercalated four-stranded cytosine-rich metazoan telomere., Kang C, Berger I, Lockshin C, Ratliff R, Moyzis R, Rich A, Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3874-8. PMID:7731999
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