293d | pdb_0000293d
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INTERACTION BETWEEN THE LEFT-HANDED Z-DNA AND POLYAMINE-2: THE CRYSTAL STRUCTURE OF THE D(CG)3 AND SPERMIDINE COMPLEX
Overview
This paper deals with the crystal structure of d(CG)3-spermidine complex., The DNA fragment, d(CG)3, was crystallized with, N-(2-amino-propyl)-1,4-diamino-butane, PA(34), spermidine. The results of, its X-ray crystallographic analysis showed many intermolecular contacts, between d(CG)3 and spermidine, but the binding mode of spermidine to the, d(CG)3 molecule is different from that of the d(CG)3 and, N-(2-amino-ethyl)-1,4-diamino-butane [PA(24)] complex: a spermidine, molecule bound to the d(CG)3 and its symmetrically related neighboring, d(CG)3 molecules through the water molecules with hydrogen bonds, while, one PA(24) molecule connected directly to one d(CG)3 molecule, but not to, its neighboring d(CG)3 molecule. In the crystal, the d(CG)3 molecule was, the left-handed Z-form, and three magnesium cations and a sodium cation, were observed around the d(CG)3 moiety with different binding modes from, the case of the d(CG)3-PA(24) complex.
About this Structure
293D is a Protein complex structure of sequences from [1] with SPD, MG and NA as ligands. Full crystallographic information is available from OCA.
Reference
Interaction between the left-handed Z-DNA and polyamine-2. The crystal structure of the d(CG)3 and spermidine complex., Ohishi H, Nakanishi I, Inubushi K, van der Marel G, van Boom JH, Rich A, Wang AH, Hakoshima T, Tomita K, FEBS Lett. 1996 Aug 5;391(1-2):153-6. PMID:8706905
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