2a4g | pdb_00002a4g
Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound
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Overview
We have discovered that introduction of appropriate amino acid derivatives, at P'2 position improved the binding potency of P3-capped alpha-ketoamide, inhibitors of HCV NS3 serine protease. X-ray crystal structure of one of, the inhibitors (43) bound to the protease revealed the importance of the, P'2 moiety.
About this Structure
2A4G is a Protein complex structure of sequences from Hepatitis c virus with ZN and UNH as ligands. Full crystallographic information is available from OCA.
Reference
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency., Arasappan A, Njoroge FG, Chan TY, Bennett F, Bogen SL, Chen K, Gu H, Hong L, Jao E, Liu YT, Lovey RG, Parekh T, Pike RE, Pinto P, Santhanam B, Venkatraman S, Vaccaro H, Wang H, Yang X, Zhu Z, Mckittrick B, Saksena AK, Girijavallabhan V, Pichardo J, Butkiewicz N, Ingram R, Malcolm B, Prongay A, Yao N, Marten B, Madison V, Kemp S, Levy O, Lim-Wilby M, Tamura S, Ganguly AK, Bioorg Med Chem Lett. 2005 Oct 1;15(19):4180-4. PMID:16087332
Page seeded by OCA on Tue Jan 29 17:54:13 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Hepatitis c virus
- Protein complex
- Arasappan, A.
- Bennett, F.
- Bogen, S.L.
- Butkiewicz, N.
- Chan, T.Y.
- Chen, K.
- Ganguly, A.K.
- Girijavallabhan, V.
- Gu, H.
- Hong, L.
- Ingram, R.
- Jao, E.
- Kemp, S.
- Levy, O.
- Lim-Wilby, M.
- Liu, Y.T.
- Lovey, R.G.
- Malcolm, B.
- Marten, B.
- Mckittrick, B.
- Njoroge, F.G.
- Parekh, T.
- Pichardo, J.
- Pike, R.E.
- Pinto, P.
- Prongay, A.J.
- Saksena, A.K.
- Santhanam, B.
- Tamura, S.
- V., Madison
- Vaccaro, H.
- Venkatraman, S.
- Wang, H.
- Yang, X.
- Yao, N.
- Zhu, Z.
- UNH
- ZN
- Virus/viral protein
