2b2s | pdb_00002b2s
Crystal structure of an oxoferryl species of catalase-peroxidase KATG at pH7.5
|
Overview
The catalase reaction of catalase-peroxidases involves catalase-specific, features built into a peroxidase core. An arginine, 20 A from the, active-site heme, acts as a molecular switch moving between two, conformations, one that activates heme oxidation and one that activates, oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway, in a peroxidase. The influence of the arginine is imparted to the heme, through its association with or dissociation from a tyrosinate that, modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi, electron interaction of the heme with the adduct Trp.
About this Structure
2B2S is a Single protein structure of sequence from Burkholderia pseudomallei with NA, HEM and O as ligands. Active as Catalase, with EC number 1.11.1.6 Full crystallographic information is available from OCA.
Reference
A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases., Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC, EMBO Rep. 2005 Dec;6(12):1156-62. PMID:16211084
Page seeded by OCA on Tue Jan 29 18:15:12 2008
