2g9c | pdb_00002g9c
|
Modified pyrimidines Specifically bind the purine riboswitch
Overview
The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized.
About this Structure
2G9C is a Protein complex structure of sequences from [1] with ACT, NCO and 3AY as ligands. Full crystallographic information is available from OCA.
Reference
Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:17076468
Page seeded by OCA on Tue Jan 29 19:54:41 2008
