Group:MUZIC:XIN

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Xin actin-binding repeat-containing protein 1 (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins.

Sequence Annotation

Function

[1]

Interactions with other proteins

Xin directly binds the EVH1 domain proteins Mena and VASP <ref name="pmid16631741">.




Clinical significance

1wlh, 1qfh – FLN rod domain – Dictyostelium discoideum

References

  1. ↑ Clark AR, Sawyer GM, Robertson SP, Sutherland-Smith AJ. Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders. Hum Mol Genet. 2009 Dec 15;18(24):4791-800. Epub 2009 Sep 22. PMID:19773341 doi:10.1093/hmg/ddp442


References

https://www.uniprot.org/uniprot/Q702N8

Proteopedia Page Contributors and Editors (what is this?)

Georg Mlynek, Jaime Prilusky, Nikos Pinotsis

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