3sfk | pdb_00003sfk
From Proteopedia
Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM267
Template:ABSTRACT PUBMED 21696174
About this Structure
3sfk is a 1 chain structure with sequence from Plasmodium falciparum 3d7. Full crystallographic information is available from OCA.
Reference
- Coteron JM, Marco M, Esquivias J, Deng X, White KL, White J, Koltun M, El Mazouni F, Kokkonda S, Katneni K, Bhamidipati R, Shackleford D, Barturen I, Ferrer S, Jimenez-Diaz MB, Gamo FJ, Goldsmith EJ, Charman B, Bathurst I, Floyd D, Matthews D, Burrows JN, Rathod PK, Charman SA, Phillips MA. Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. J Med Chem. 2011 Jun 22. PMID:21696174 doi:10.1021/jm200592f
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Dihydroorotate dehydrogenase
- Plasmodium falciparum 3d7
- Deng, X.
- Phillips, M.
- Alpha beta barrel oxidoreductase
- Alpha beta fold
- Flavoprotein
- Fmn
- Inhibitor dsm267
- Mitochondrion inner membrane
- Oxidoreductase-oxidoreductase inhibitor complex
- Plasmodium falciparum membrane mitochondrion
- Pyrimidine biosynthesis
