Caspase

Template:STRUCTURE 3d6f

Caspase (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP. CASP-1 cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. CASP-3 interacts with CASP-8 and CASP-9 during cell apoptosis.

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky