2xqw | pdb_00002xqw
From Proteopedia
STRUCTURE OF FACTOR H DOMAINS 19-20 IN COMPLEX WITH COMPLEMENT C3D
About this Structure
2xqw is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kajander T, Lehtinen MJ, Hyvarinen S, Bhattacharjee A, Leung E, Isenman DE, Meri S, Goldman A, Jokiranta TS. Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement. Proc Natl Acad Sci U S A. 2011 Feb 1. PMID:21285368 doi:10.1073/pnas.1017087108
- Jokiranta TS, Jaakola VP, Lehtinen MJ, Parepalo M, Meri S, Goldman A. Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome. EMBO J. 2006 Apr 19;25(8):1784-94. Epub 2006 Apr 6. PMID:16601698
- Lehtinen MJ, Rops AL, Isenman DE, van der Vlag J, Jokiranta TS. Mutations of factor H impair regulation of surface-bound C3b by three mechanisms in atypical hemolytic uremic syndrome. J Biol Chem. 2009 Jun 5;284(23):15650-8. Epub 2009 Apr 7. PMID:19351878 doi:10.1074/jbc.M900814200
