2viy | pdb_00002viy
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HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(PENTYLSULFONYL)BENZAMIDE
Overview
Inhibition of the aspartyl protease BACE-1 has the potential to deliver a, disease-modifying therapy for Alzheimer's disease. Herein, is described, the lead generation effort which resulted, with the support of X-ray, crystallography, in the discovery of potent inhibitors based on a hydroxy, ethylamine (HEA) transition-state mimetic. These inhibitors were capable, of lowering amyloid production in a cell-based assay.
About this Structure
2VIY is a Single protein structure of sequence from Homo sapiens with VG3 as ligand. Active as Memapsin 2, with EC number 3.4.23.46 Known structural/functional Site: AC1. Full crystallographic information is available from OCA.
Reference
BACE-1 inhibitors Part 1: Identification of novel hydroxy ethylamines (HEAs)., Clarke B, Demont E, Dingwall C, Dunsdon R, Faller A, Hawkins J, Hussain I, Macpherson D, Maile G, Matico R, Milner P, Mosley J, Naylor A, O'Brien A, Redshaw S, Riddell D, Rowland P, Soleil V, Smith KJ, Stanway S, Stemp G, Sweitzer S, Theobald P, Vesey D, Walter DS, Ward J, Wayne G, Bioorg Med Chem Lett. 2007 Dec 15;. PMID:18171614
Page seeded by OCA on Thu Jan 31 11:02:01 2008
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- Homo sapiens
- Memapsin 2
- Single protein
- Brien, A.O.
- Clarke, B.
- Demont, E.
- Dingwall, C.
- Dunsdon, R.
- Faller, A.
- Hawkins, J.
- Hussain, I.
- Macpherson, D.
- Maile, G.
- Matico, R.
- Milner, P.
- Mosley, J.
- Naylor, A.
- Redshaw, S.
- Riddell, D.
- Rowland, P.
- Smith, K.
- Soleil, V.
- Stanway, S.
- Stemp, G.
- Sweitzer, S.
- Theobald, P.
- Vesey, D.
- Walter, D.S.
- Ward, J.
- Wayne, G.
- VG3
- Alternative splicing
- Asp-2
- Aspartyl protease
- Bace-1
- Beta-secretase
- Beta-site app cleaving enzyme
- Glycoprotein
- Hydrolase
- Memapsin-2
- Membrane
- Protease
- Transmembrane
- Zymogen
