Shiga toxin
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Introduction
Shiga Toxins are a family of AB5 toxins which cause dysentery in humans. They are primarily secreted by Shiga toxin-encoding Escherichia coli (STEC), notably by the 0157:H7 strain.Cite error: Closing </ref> missing for <ref> tag
Structure
Shiga Toxin consists consists of an AB5 hexamer.[1] The 5 subunit B pentamer interacts with a single A subunit via a C-terminal helix and 4 stranded beta-sheet.Cite error: Closing </ref> missing for <ref> tag The B subunit is necessary for binding to eukaryotic cell surface, where it is then endocytosed and proteolytically cleaved into two active A subunits and a B subunit. On the A subunit Tyr77, Tyr114, Glu167, Arg170, and Trp203 are all essential in glycosidic activity.<ref name=Di>
