2bge | pdb_00002bge
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STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS
Overview
Using structure-based design, a new class of inhibitors of protein, tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the, 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.
Disease
Known diseases associated with this structure: Abdominal body fat distribution, modifier of OMIM:[176885], Insulin resistance, susceptibility to OMIM:[176885]
About this Structure
2BGE is a Single protein structure of sequence from Homo sapiens with T2D as ligand. Active as Protein-tyrosine-phosphatase, with EC number 3.1.3.48 Known structural/functional Site: AC1. Full crystallographic information is available from OCA.
Reference
Structure-based design of protein tyrosine phosphatase-1B inhibitors., Black E, Breed J, Breeze AL, Embrey K, Garcia R, Gero TW, Godfrey L, Kenny PW, Morley AD, Minshull CA, Pannifer AD, Read J, Rees A, Russell DJ, Toader D, Tucker J, Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7. PMID:15863305
Page seeded by OCA on Sun Feb 3 10:23:44 2008
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- Homo sapiens
- Protein-tyrosine-phosphatase
- Single protein
- Black, E.
- Breed, J.
- Breeze, A.L.
- Embrey, K.
- Garcia, R.
- Gero, T.W.
- Godfrey, L.
- Kenny, P.W.
- Minshull, C.A.
- Morley, A.D.
- Pannifer, A.D.
- Read, J.
- Rees, A.
- Russell, D.J.
- Toader, D.
- Tucker, J.
- T2D
- 1
- 1-dioxide template
- 2
- 5-thiadiazolidin-3-one-1
- Hydrolase
- Protein tyrosine phosphatase
