2bkf | pdb_00002bkf
STRUCTURE OF THE PB1 DOMAIN OF NBR1
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Overview
The scaffold protein NBR1 is involved in signal transmission downstream of, the serine/protein kinase from the giant muscle protein titin. Its, N-terminal Phox and Bem1p (PB1) domain plays a critical role in mediating, protein-protein interactions with both titin kinase and with another, scaffold protein, p62. We have determined the crystal structure of the PB1, domain of NBR1 at 1.55A resolution. It reveals a type-A PB1 domain with, two negatively charged residue clusters. We provide a structural, perspective on the involvement of NBR1 in the titin kinase signalling, pathway.
About this Structure
2BKF is a Single protein structure of sequence from Homo sapiens with GOL as ligand. Known structural/functional Site: AC1. Full crystallographic information is available from OCA.
Reference
Crystal structure of the PB1 domain of NBR1., Muller S, Kursula I, Zou P, Wilmanns M, FEBS Lett. 2006 Jan 9;580(1):341-4. Epub 2005 Dec 19. PMID:16376336
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