2qjy | pdb_00002qjy
Crystal structure of rhodobacter sphaeroides double mutant with stigmatellin and UQ2
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Overview
The cytochrome bc(1) complex (bc(1)) is a major contributor to the proton, motive force across the membrane by coupling electron transfer to proton, translocation. The crystal structures of wild type and mutant bc(1), complexes from the photosynthetic purple bacterium Rhodobacter sphaeroides, (Rsbc(1)), stabilized with the quinol oxidation (Q(P)) site inhibitor, stigmatellin alone or in combination with the quinone reduction (Q(N)), site inhibitor antimycin, were determined. The high quality electron, density permitted assignments of a new metal-binding site to the, cytochrome c(1) subunit and a number of lipid and detergent molecules., Structural differences between Rsbc(1) and its mitochondrial counterparts, are mostly extra membranous and provide a basis for understanding the, function of the predominantly longer sequences in the bacterial subunits., Functional implications for the bc(1) complex are derived from analyses of, 10 independent molecules in various crystal forms and from comparisons, with mitochondrial complexes.
About this Structure
2QJY is a Protein complex structure of sequences from Rhodobacter sphaeroides with BGL, SR, CL, NA, HEM, SMA, LOP, UQ2 and FES as ligands. Active as Ubiquinol--cytochrome-c reductase, with EC number 1.10.2.2 Known structural/functional Sites: AC1, AC2, AC3, AC4, AC5, AC6, AC7, AC8, AC9, BC1, BC2, BC3, BC4, BC5, BC6, BC7, BC8, BC9, CC1, CC2, CC3, CC4, CC5, CC6, CC7, CC8, CC9, DC1, DC2, DC3, DC4, DC5, DC6, DC7, DC8, DC9, EC1, EC2, EC3, EC4, EC5, EC6, EC7, EC8, EC9, FC1, FC2, FC3, FC4, FC5, FC6, FC7, FC8, FC9, GC1, GC2 and GC3. Full crystallographic information is available from OCA.
Reference
Inhibitor-complexed Structures of the Cytochrome bc1 from the Photosynthetic Bacterium Rhodobacter sphaeroides., Esser L, Elberry M, Zhou F, Yu CA, Yu L, Xia D, J Biol Chem. 2008 Feb 1;283(5):2846-57. Epub 2007 Nov 26. PMID:18039651
Page seeded by OCA on Wed Feb 13 08:18:31 2008
