3qi2 | pdb_00003qi2
From Proteopedia
A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco
Template:ABSTRACT PUBMED 22383884
About this Structure
3qi2 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP. A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis. PLoS Pathog. 2012 Feb;8(2):e1002553. Epub 2012 Feb 23. PMID:22383884 doi:10.1371/journal.ppat.1002553
- Sammond DW, Eletr ZM, Purbeck C, Kimple RJ, Siderovski DP, Kuhlman B. Structure-based protocol for identifying mutations that enhance protein-protein binding affinities. J Mol Biol. 2007 Aug 31;371(5):1392-404. Epub 2007 Jun 8. PMID:17603074 doi:10.1016/j.jmb.2007.05.096
- Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP. Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. Nature. 2002 Apr 25;416(6883):878-81. PMID:11976690 doi:https://dx.doi.org/10.1038/416878a
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Heterotrimeric G-protein GTPase
- Homo sapiens
- Bosch, D E.
- Kimple, A J.
- Miley, M J.
- Siderovski, D P.
- Willard, F S.
- Adp-ribosylation
- All-helical domain
- Arginine finger
- Goloco motif
- Gtp binding
- Guanine nucleotide dissociation inhibitor
- Lipoprotein
- Nucleotide binding
- Ras-like domain
- Rgs14 goloco
- Signaling protein
- Transducer
