1ms1 | pdb_00001ms1

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File:1ms1.png

Template:STRUCTURE 1ms1

Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA)

Template:ABSTRACT PUBMED 12419220

About this Structure

1ms1 is a 2 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.

Reference

  1. Buschiazzo A, Amaya MF, Cremona ML, Frasch AC, Alzari PM. The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis. Mol Cell. 2002 Oct;10(4):757-68. PMID:12419220
  2. Demir O, Roitberg AE. Modulation of catalytic function by differential plasticity of the active site: case study of Trypanosoma cruzi trans-sialidase and Trypanosoma rangeli sialidase. Biochemistry. 2009 Apr 21;48(15):3398-406. PMID:19216574 doi:10.1021/bi802230y

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OCA

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