Hyaluronidase

spinqualitylabelsall models Hyaluronidase complex with hyaluronic acid disaccharide and dimethylarsinate, 1c82 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Hyaluronidase (HU) hydrolyzes complex carbohydrates such as hyaluronan which is part of the extracellular matrix. The hydrolysis increases tissue permeability. HU is used in medicine to speed drug delivery. Hyaluronic acid (HUA) is a popular dermal filler material. Superposition of the EGF-like domain of hyaluronidase-1 (yellow) and the heparin-binding EGF-like growth factor (light blue). The three disulfide bonds of the EGF domains (highlighted red) exhibit the same pattern in the primary structure and are located in similar positions in the 3D structure. Hyaluronidase cleaves the β1,4-glycosidic bond of the glycosaminoglycan hyaluronan 3D structures of hyaluronidase 1egu, 2brw – SpHU – Streptococcus pneumoniae 1n7n, 1n7o, 1n7p – SpHU (mutant) 1fcq, 1fcu – bHU – bee 1f1s – SaHU – Streptococcus agalactiae 2c3f, 2dp5, 2yw0, 2yx2, 2wb3, 2wh7 - SpyHU – Streptococcus pyogenes 2cbi, 2w1q, 2w1s - CpHU – Clostridium perfringens 2jnk - CpHU residues 1498-1628]] - NMR 2atm - HU – Vespula vulgaris 2pe4 – HU-1 – human Hyaluronidase binary complex 1c82 – SpHU + HUA disaccharide 1f9g – SpHU + ascorbate 2brv– SpHU + malonate 1fcv - bHU + HUA 1i8q - SaHU + HUA disaccharide 1loh, 1lxk - SpHU + glucuronic acid 1n7q, 1n7r - SpHU (mutant) + glucuronic acid 1lxm - SaHU + glucuronic acid 1ojm, 1ojp - SpHU + condroitin disaccharide 1ojn, 1ojo - SpHU (mutant) + condroitin disaccharide 1w3y - SpHU + palmitoyl-vitamin C 2cbj - CpHU + PugNac 2j1a - CpHU + galactose 2j1e - CpHU + LacNac 2j7m, 2w1u, 2wdb - CpHU + carbohydrates 2j62 - CpHU + GlcNac-statin 2brp – SpHU + inbhibitor 2j88 - bHU + FAB 2yvv - SpyHU + lactose 3eka - SpyHU + ascorbate Reference Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis., Chao KL, Muthukumar L, Herzberg O, Biochemistry. 2007 Jun 12;46(23):6911-20. Epub 2007 May 16. PMID:17503783 Created with the participation of Osnat Herzberg, Eran Hodis, Joel L. Sussman, Jaime Prilusky.

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Alexander Berchansky, Michal Harel, Joel L. Sussman