2wgx | pdb_00002wgx
From Proteopedia
HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y236F-N239Y-T253I-N268D
Template:ABSTRACT PUBMED 19515728
About this Structure
2wgx is a 2 chain structure of P53 with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Khoo KH, Joerger AC, Freund SM, Fersht AR. Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core. Protein Eng Des Sel. 2009 Jul;22(7):421-30. Epub 2009 Jun 10. PMID:19515728 doi:10.1093/protein/gzp018
- Joerger AC, Allen MD, Fersht AR. Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem. 2004 Jan 9;279(2):1291-6. Epub 2003 Oct 8. PMID:14534297 doi:10.1074/jbc.M309732200
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Fersht, A R.
- Joerger, A C.
- Khoo, K H.
- Apoptosis
- Cancer
- Cell cycle
- Dna-binding domain
- Dna-binding protein
- Li-fraumeni syndrome
- Metal binding
- Nuclear protein
- Nucleus
- P53
- P63
- P73
- Protein stabilization
- Second-site suppressor mutation
- Superstable mutant
- Transcription regulation
- Tumor suppressor
