3t5u | pdb_00003t5u

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File:3t5u.jpg

Template:STRUCTURE 3t5u

Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide

Template:ABSTRACT PUBMED 21952494

About this Structure

3t5u is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Di Fiore A, Maresca A, Alterio V, Supuran CT, De Simone G. Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II. Chem Commun (Camb). 2011 Nov 14;47(42):11636-8. Epub 2011 Sep 26. PMID:21952494 doi:10.1039/c1cc14575d
  2. Eriksson AE, Jones TA, Liljas A. Refined structure of human carbonic anhydrase II at 2.0 A resolution. Proteins. 1988;4(4):274-82. PMID:3151019 doi:https://dx.doi.org/10.1002/prot.340040406
  3. Scott AD, Phillips C, Alex A, Flocco M, Bent A, Randall A, O'Brien R, Damian L, Jones LH. Thermodynamic optimisation in drug discovery: a case study using carbonic anhydrase inhibitors. ChemMedChem. 2009 Dec;4(12):1985-9. PMID:19882701 doi:10.1002/cmdc.200900386

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