4djz | pdb_00004djz

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Template:STRUCTURE 4djz

File:4djz.png

Catalytic fragment of masp-1 in complex with its specific inhibitor developed by directed evolution on sgci scaffold

Template:ABSTRACT PUBMED 22511776

About this Structure

4djz is a 6 chain structure with sequence from Homo sapiens and Schistocerca gregaria. Full crystallographic information is available from OCA.

Reference

  1. Heja D, Harmat V, Fodor K, Wilmanns M, Dobo J, Kekesi KA, Zavodszky P, Gal P, Pal G. Monospecific inhibitors show that both mannan-binding lectin-associated serine protease (MASP)-1 and -2 are essential for lectin pathway activation and reveal structural plasticity of MASP-2. J Biol Chem. 2012 Apr 16. PMID:22511776 doi:10.1074/jbc.M112.354332

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OCA

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