2x24 | pdb_00002x24

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Template:STRUCTURE 2x24

File:2x24.png

BOVINE ACC2 CT DOMAIN IN COMPLEX WITH INHIBITOR

Template:ABSTRACT PUBMED 21515056

About this Structure

2x24 is a 2 chain structure of Acetyl-CoA carboxylase with sequence from Bos taurus. Full crystallographic information is available from OCA.

See Also

Reference

  1. Bengtsson C, Blaho S, Saitton DB, Brickmann K, Broddefalk J, Davidsson O, Drmota T, Folmer R, Hallberg K, Hallen S, Hovland R, Isin E, Johannesson P, Kull B, Larsson LO, Lofgren L, Nilsson KE, Noeske T, Oakes N, Plowright AT, Schnecke V, Stahlberg P, Sorme P, Wan H, Wellner E, Oster L. Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats. Bioorg Med Chem. 2011 May 15;19(10):3039-53. Epub 2011 Apr 13. PMID:21515056 doi:10.1016/j.bmc.2011.04.014

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