2gs7 | pdb_00002gs7

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File:2gs7.png

Template:STRUCTURE 2gs7

Crystal Structure of the inactive EGFR kinase domain in complex with AMP-PNP

Template:ABSTRACT PUBMED 16777603

About this Structure

2gs7 is a 2 chain structure of Epidermal Growth Factor Receptor with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Zhang X, Gureasko J, Shen K, Cole PA, Kuriyan J. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell. 2006 Jun 16;125(6):1137-49. PMID:16777603 doi:10.1016/j.cell.2006.05.013
  2. Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J. Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature. 2007 Nov 29;450(7170):741-4. PMID:18046415 doi:nature05998

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