3i25 | pdb_00003i25
From Proteopedia
Potent Beta-Secretase 1 hydroxyethylene Inhibitor
About this Structure
3i25 is a 3 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Bjorklund C, Adolfsson H, Jansson K, Lindberg J, Vrang L, Hallberg A, Rosenquist S, Samuelsson B. Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1' alkoxy residues and an aminoethylene (AE) central core. Bioorg Med Chem. 2010 Feb 15;18(4):1711-23. Epub 2010 Jan 11. PMID:20122837 doi:10.1016/j.bmc.2009.12.051
