2zc9 | pdb_00002zc9
From Proteopedia
Thrombin in complex with Inhibitor
About this Structure
2zc9 is a 3 chain structure of Hirudin and Thrombin with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Baum B, Muley L, Heine A, Smolinski M, Hangauer D, Klebe G. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin. J Mol Biol. 2009 Aug 21;391(3):552-64. Epub 2009 Jun 9. PMID:19520086 doi:10.1016/j.jmb.2009.06.016
- Baum B, Mohamed M, Zayed M, Gerlach C, Heine A, Hangauer D, Klebe G. More than a simple lipophilic contact: a detailed thermodynamic analysis of nonbasic residues in the s1 pocket of thrombin. J Mol Biol. 2009 Jul 3;390(1):56-69. Epub 2009 May 3. PMID:19409395 doi:10.1016/j.jmb.2009.04.051
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Hirudo medicinalis
- Homo sapiens
- Thrombin
- Baum, B.
- Heine, A.
- Klebe, G.
- Acute phase
- Blood clotting-hydrolase inhibitor complex
- Blood clotting/serine protease inhibitor
- Blood coagulation
- Cleavage on pair of basic residue
- Disease mutation
- Gamma-carboxyglutamic acid
- Glycoprotein
- Hydrolase
- Kringle
- Secreted
- Sulfation
- Zymogen
