3ee0 | pdb_00003ee0

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File:3ee0.png

Template:STRUCTURE 3ee0

Crystal Structure of the W215A/E217A Mutant of Human Thrombin (space group P2(1)2(1)2(1))

Template:ABSTRACT PUBMED 15252033

About this Structure

3ee0 is a 2 chain structure of Thrombin with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Pineda AO, Chen ZW, Caccia S, Cantwell AM, Savvides SN, Waksman G, Mathews FS, Di Cera E. The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J Biol Chem. 2004 Sep 17;279(38):39824-8. Epub 2004 Jul 13. PMID:15252033 doi:https://dx.doi.org/10.1074/jbc.M407272200
  2. Gandhi PS, Page MJ, Chen Z, Bush-Pelc L, Di Cera E. Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A. J Biol Chem. 2009 Sep 4;284(36):24098-105. Epub 2009 Jul 8. PMID:19586901 doi:10.1074/jbc.M109.025403

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