3cse | pdb_00003cse

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Template:STRUCTURE 3cse

File:3cse.png

Candida glabrata Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)

Template:ABSTRACT PUBMED 18804036

About this Structure

3cse is a 2 chain structure of Dihydrofolate reductase with sequence from Candida glabrata. Full crystallographic information is available from OCA.

See Also

Reference

  1. Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC. Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase. Chem Biol. 2008 Sep 22;15(9):990-6. PMID:18804036 doi:S1074-5521(08)00280-9
  2. Liu J, Bolstad DB, Bolstad ES, Wright DL, Anderson AC. Towards new antifolates targeting eukaryotic opportunistic infections. Eukaryot Cell. 2009 Apr;8(4):483-6. Epub 2009 Jan 23. PMID:19168759 doi:10.1128/EC.00298-08

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