1e0f | pdb_00001e0f

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File:1e0f.png

Template:STRUCTURE 1e0f

CRYSTAL STRUCTURE OF THE HUMAN ALPHA-THROMBIN-HAEMADIN COMPLEX: AN EXOSITE II-BINDING INHIBITOR

Template:ABSTRACT PUBMED 11060016

About this Structure

1e0f is a 9 chain structure of Thrombin with sequence from Haemadipsa sylvestris and Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Richardson JL, Kroger B, Hoeffken W, Sadler JE, Pereira P, Huber R, Bode W, Fuentes-Prior P. Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor. EMBO J. 2000 Nov 1;19(21):5650-60. PMID:11060016 doi:10.1093/emboj/19.21.5650
  2. Strube KH, Kroger B, Bialojan S, Otte M, Dodt J. Isolation, sequence analysis, and cloning of haemadin. An anticoagulant peptide from the Indian leech. J Biol Chem. 1993 Apr 25;268(12):8590-5. PMID:8473305
  3. Bode W, Turk D, Karshikov A. The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships. Protein Sci. 1992 Apr;1(4):426-71. PMID:1304349
  4. Bode W. The structure of thrombin: a janus-headed proteinase. Semin Thromb Hemost. 2006 Apr;32 Suppl 1:16-31. PMID:16673263 doi:10.1055/s-2006-939551

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