1l8a | pdb_00001l8a

Ligands:

MG, TDP

Activity:

Structural annotation:
Resources:	CATH : 1L8Aa03, 1L8Ab03 InterPro : Ipr009014, Ipr004660, Ipr005474 Pfam : PF00456 SCOP : d1l8aa3, d1l8aa2, d1l8aa1, d1l8ab3, d1l8ab2, d1l8ab1 UniProt : P0AFG8

Functional annotation:
Cellular component:	membrane fraction
Biological process:	glycolysis
Molecular function:	pyruvate dehydrogenase (acetyl-transferring) activity metal ion binding oxidoreductase activity magnesium ion binding protein binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

About this Structure

1l8a is a 2 chain structure of Pyruvate dehydrogenase with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Arjunan P, Nemeria N, Brunskill A, Chandrasekhar K, Sax M, Yan Y, Jordan F, Guest JR, Furey W. Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution. Biochemistry. 2002 Apr 23;41(16):5213-21. PMID:11955070
Ciszak EM, Korotchkina LG, Dominiak PM, Sidhu S, Patel MS. Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase. J Biol Chem. 2003 Jun 6;278(23):21240-6. Epub 2003 Mar 21. PMID:12651851 doi:https://dx.doi.org/10.1074/jbc.M300339200