3cde | pdb_00003cde
From Proteopedia
Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor
About this Structure
3cde is a 2 chain structure of RNA polymerase with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.
See Also
Reference
- Li LS, Zhou Y, Murphy DE, Stankovic N, Zhao J, Dragovich PS, Bertolini T, Sun Z, Ayida B, Tran CV, Ruebsam F, Webber SE, Shah AM, Tsan M, Showalter RE, Patel R, Lebrun LA, Bartkowski DM, Nolan TG, Norris DA, Kamran R, Brooks J, Sergeeva MV, Kirkovsky L, Zhao Q, Kissinger CR. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)- 5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3446-55. Epub 2008 Mar 5. PMID:18457949 doi:10.1016/j.bmcl.2008.02.072
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Hepatitis c virus
- RNA-directed RNA polymerase
- Han, Q.
- Kissinger, C R.
- Showalter, R E.
- Zhao, Q.
- Atp-binding
- Host-virus interaction
- Hydrolase
- Metal-binding
- Nucleotide-binding
- Nucleotidyltransferase
- Protein-ligand complex
- Ribonucleoprotein
- Rna replication
- Rna-binding
- Rna-directed rna polymerase
- Transcription
- Transcription regulation
- Transferase
- Viral nucleoprotein
- Virion
